Scientist I - Scientist I (Animal Models & Pathogenesis) Military HIV Research Program

Company: Henry M Jackson Foundation For The Advan
Location: Silver Spring
Posted on: September 13, 2020

Job Description:

Scientist I - Scientist I (Animal Models & Pathogenesis) Military HIV Research Program. Henry M Jackson Foundation For The Advan. -. Silver Spring, MD. Join the HJF Team !. HJF is seeking a Scientist I (Animal Models & Pathogenesis) to support the Laboratory of Vaccine Immunology Department in Military HIV Research Program (MHRP) located at Walter Reed Army Institute of Research (WRAIR) in Silver Spring, MD. HJF provides scientific, technical and programmatic support services to MHRP.. The incumbent will be responsible for conducting research projects involving the virus-specific adaptive immune responses in animal models and humans at the Walter Reed Army Institute of Research (WRAIR). Incumbent will work independently to formulate research questions and design and execute experiments to test hypotheses pertaining to the mission of the Animal Models & Viral Persistence group and the US MHRP program. Specifically, he/she will investigate HIV-, SIV-, and SARS-CoV-2-specific T cell responses following vaccination and infection. Research will focus on measuring the magnitude and functional quality of virus-specific T cells by intracellular cytokine staining and flow cytometry, and other relevant assays. Additional immunogenicity measurements will be performed as needed. Model systems will include nonhuman primates, humans, and small animals. State-of-the-art single-cell immunological and molecular biology techniques will be applied. The incumbent should be able to apply the scientific principles and concepts developed in these projects for potential inventions and products.. The proposed work supports the mission of the US MHRP. This research will help inform prophylactic and therapeutic vaccine strategies against viral infections, which would significantly improve the capacity of the US Military to reduce infection rates and achieve sustained HIV-1 remission.. Responsibilities:. Formulates experimental hypotheses, designs and implements experimental protocol.. Develops necessary new technologies and protocols.. Collects, processes and interprets experimental data.. Trains and supervises technical staff and junior level scientists.. Coordinates with other technical and professional staff.. Must be proficient in immunologic and/or molecular biology techniques with up-to-date knowledge of relevant HIV-1 and immunology literature.. Performs data analysis, prepares graphical representation of data, makes oral presentations summarizing research progress, prepares manuscripts for publication in peer reviewed scientific journals, assists in the preparation of scientific reports for funded projects, presents research data at in-house meetings and at national and international scientific conferences.. Contributes to scientific discussions during data presentations by providing constructive comments and suggestions for additional experimentation, future directions.. Provides collaborative assistance to other Research Scientists that require the incumbent's expertise.. Performs specialized laboratory research utilizing experimental protocols, involving analytical techniques such as polychromatic flow cytometry, multiplex quantitative PCR and single-cell RNA-seq.. Processes human and non-human primate tissue samples infected with SIV/HIV, SARS-CoV-2 and performs live cell sorting in BSL-2+ laboratory.. Maintains detailed records of experiments.. Serves as an in-house consultant and takes lead on scientific collaborations both within and outside the institution as it pertains to US-MHRP mission in consultation with supervisors.. Attends all training and safety classes conducted by WRAIR and HMJF.. Completes other projects and duties as assigned, to include general laboratory maintenance and housekeeping.. Required Knowledge, Skills and Abilities: Knowledge of virology (ideally HIV-1), immunology, flow cytometry, PCR, and standard laboratory techniques is required. The incumbent should have excellent communication skills including the ability to efficiently prepare public seminars and research papers; grant-writing experience is optional. He/she should have a strong publication record as evidenced by first-author publications in virology (preferably HIV-1), immunology, or cell biology. They should have the ability to work in an independent capacity, be able to design experiments, troubleshoot technical procedures, and be capable of supervising junior staff.. Minimum Education: Doctoral degree is required in Immunology, Virology, or related.. Minimum Experience/ Training Requirements: 2 – 5 years of relevant experience is required.. Physical Capabilities: Work involves long periods of standing, handling numerous chemicals and biological samples in the laboratory.. Supervisory Responsibilities: Provide guidance to laboratory staff and train junior staff members.. Work Environment: Laboratory environment; requires working with human and animal cells/cell lines, HIV-1, SARS-CoV-2, blood, and or bodily fluids; may require working long hours including evenings and weekends.. Background/Security:Must have lived in the U.S. 3 out of the past 5 years; eligible to obtain and maintain a Tier I investigation/ Public Trust and a Common Access Card (CAC).. Employment with HJF is contingent upon successful completion of a background check, which may include, but is not limited to, contacting your professional references, verification of previous employment, addresses, education, and credentials, a criminal background check, drug screening, and a department of motor vehicle (DMV) check.. Any qualifications to be considered as equivalents, in lieu of stated minimums, require the prior approval of the Chief Human Resources Officer.. Experience. Required. 2 - 5 years: 2 – 5 years of relevant experience is required.. Education. Required. Doctorate (Academic) or better. Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities. The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c). 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