Research Associate - Microbiology & Molecular Genetics
Company: Odyssey Systems Consulting Group, Ltd.
Location: Silver Spring
Posted on: April 1, 2021
Odyssey Systems has an exciting new opportunity for a Research
Associate supporting the WRAIR - Department of Diarrheal Disease
Research (DDR). Diarrheal diseases, notably Shigella, are a major
source of morbidity among deployed U.S. military and a significant
threat to readiness. To that end, BDB aims to develop a safe and
effective vaccine against multiple Shigella strains to protect
personnel overseas and keep Soldiers in the fight.
Duties include, but not limited to:
The Research Associate will provide expertise in the areas of
immunological research to include:
Utilize recombinant engineering of Shigella and coli to synthesize
large quantities of antigen proteins and molecules for the
production of vaccines or for the characterization of vaccines.
Use modern molecular techniques, such as real-time PCR, to carry
out the transfer and modification of genes. May include deletions
of a gene to modify antigens or bacterial behavior or creating a
mutation in a protein of interest.
Conducting bench research on Shigella (or other enteric pathogens)
to include large scale production of purified proteins and LPS,
immunogenicity, biochemistry, and mechanisms of action of Shigella
subunit vaccines or live Shigella vaccine candidates.
Assisting in the evaluation of Shigella vaccines in clinical and
pre-clinical studies to include immunizing small animals,
collecting blood, lymph nodes mucosal washes, and determining the
immune response elicited after vaccination using cellular
proliferation, antibody-secreting cell (ASC), ELISA, and immunobead
Assisting in the pre-clinical evaluation of prototype diagnostic
devices for the detection of Shigella and other enteric pathogens
from complex biological matrices such as stool.
Assisting in the daily maintenance and operations of the lab to
include media preparation, glassware and hazardous waste
management, and administrative duties such as ordering supplies and
periodic lab inventories.
Establishing and/or developing laboratory procedures and analyze
and/or evaluate research data; participate in a cooperative effort
to accomplish goals of the laboratory; maintain proficiency and
expertise in the field of research.
Utilizing professional knowledge of: theories, principles, methods,
and techniques of immunology, cell biology, and microbial
pathogenesis, such as ELISA, ASC assays, cellular proliferation
assays, western blotting, cell culture, small animal handling (such
as mice or guinea pigs), and aseptic technique.
Ability to obtain a NACI (National Agencies Check & Inquiries)
Bachelor's degree in the biological sciences
Up to 2 years of experience as a research technician in
microbiology or molecular genetics focused laboratory a plus
Demonstrated experience with basic laboratory procedures
(pipetting, buffer preparation, autoclaving)
Demonstrated experience/understanding of molecular biology (qPCR,
RT-PCR ideal), microbial pathogenesis/cellular microbiology
(Gram-neg or enteric ideal), mammalian cell culture, general
Hands-on experience or willingness to work with laboratory animals
(mice, rats, rabbits, and/or guinea pigs) involving typical
full-cycle laboratory animal handling.
Previous independent or semi-independent research projects a
Familiarity with the following research equipment is preferred but
not limited to: HPLC, PCR, Mass spectrometer, Flow Cytometers, cell
counters, cell separation devices, fermenters, lyophilizes, peptide
Familiarity with the following typical procedures is preferred but
not limited to: gel electrophoresis, protein assays, fermentation
and purifications, and immunological functional assays.
Familiarity with Microsoft Excel, Microsoft Access, Prism, and SAS
US Citizenship required
Odyssey Systems Consulting Group, is an innovative small business
committed to providing world-class technical, management, and
training support services to government and public sector clients.
We focus on people, processes, and performance to deliver superior
results. Since our inception in 1997, our commitment to mission
success and customer satisfaction has been recognized with
exponential growth and exceptional past performance ratings. We
accept challenging assignments and drive projects from the planning
stages, through implementation, and into operations and
Equal Opportunity Employer/Protected Veterans/Individuals with
Keywords: Odyssey Systems Consulting Group, Ltd., Silver Spring , Research Associate - Microbiology & Molecular Genetics, Other , Silver Spring, Maryland
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