Jr. Scientist II-XTAL
Company: Odyssey Systems Consulting Group, Ltd.
Location: Silver Spring
Posted on: August 3, 2022
We are seeking a Jr. Scientist II to join a dynamic and growing
team at the Walter Reed Army Institute of Research (WRAIR) Wound
Infection Department (WID). WID is tasked with delivering specific,
effective countermeasures for infection of combat wounds
pre-injury, at the point-of-injury, and post-injury. The Structural
Biology (XTAL) group focuses on structure-based drug designs for
microbial pathogens of military relevance. Researchers in this
group express, purify and crystallize ESKAPEE pathogen proteins of
interest and utilize sophisticated techniques such as X-ray
Crystallography and Mass Spectroscopy to model small molecule
The candidate will perform a variety of laboratory procedures and
be familiar with the field's concepts, practices, and procedures,
including, but not limited to, microbiology, immunology,
vaccinology, biochemistry, genetics, molecular biology, clinical
trials, and bioinformatics. The candidate will work independently
and as part of a scientific team to understand and resolve complex
biological questions while contributing to product development
through the analysis and interpretation of data, presentation of
data at meetings, the establishment of collaborations both internal
and external to WRAIR, the solicitation of grants and the writing
of successful proposals. Under the guidance of the Department head,
the candidate will actively pursue the scientific objectives of the
Branch and contribute significantly to the critical strategic
planning and execution of future studies.
Duties include, but not limited to:
Design, develop and deliver novel small molecule antibiotics
against MDR organisms of military relevance through structure based
Identify novel small-molecule drug candidates through in silico
screening of commercially available chemical databases and
molecular modeling of drug candidates for enhancement.
Express, purify and crystallize proteins for structure-based drug
design and perform mass spectrometry on all products.
Develop and recommend antimicrobial drug candidates for specific
targets on MDR ESKAPEE pathogens (Enterococcus species,
Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter
baumannii, Pseudomonas aeruginosa, Enterobacter cloacae, and
Draft grant proposals on structure based drug design for submission
to leadership and research steering committees.
Conduct research on projects associated with antimicrobial
development such as protein expression and purification, MIC
(minimum inhibitory concentration) studies, animal modeling,
virtual modeling of drugs bound to target proteins, etc.
Independently design experiments, make detailed observations,
analyze data, interpret results and deliver timely results.
Mentor and supervise junior scientists within the team as
Citizenship: Must be a U.S. Citizen
Education: Ph.D. in an appropriate discipline (e.g., microbiology,
immunology, Molecular Biology or biochemistry)
Experience: 3-5 years experience in protein characterization and
Experience in X-ray Crystallography.
Experience in at least one of the following areas: druggable target
identification, cloning, enzymology, protein characterization and
Strong computer skills and experience with relevant software,
including MS Office and GraphPad Prism.
Experience with microbiology of Gram-negative negative species and
antibacterial development is desired.
Must have a proven track record of securing competitive funding
from grants/proposals written and submitted.
Must have excellent presentation and oral and written communication
Ability to prioritize and work in a fast-paced and diverse
environment. Contribute individually as well as part of a highly
collaborative and productive team.
Must have proven ability to prepare precise technical summaries and
protocols and maintain appropriate documentation.
Onsite at Walter Reed Army Institute of Research (Silver Spring,
Odyssey Systems Consulting Group, is an innovative small business
committed to providing world-class technical, management, and
training support services to government and public sector clients.
We focus on people, processes, and performance to deliver superior
results. Since our inception in 1997, our commitment to mission
success and customer satisfaction has been recognized with
exponential growth and exceptional past performance ratings. We
accept challenging assignments and drive projects from the planning
stages, through implementation, and into operations and
Please note: Final compensation for this position will be
determined by various factors such as the Federal Government
contract labor categories and contract wage rates, relevant work
experience, specific skills and competencies, geographic location,
education, and certifications.
Equal Opportunity Employer/Protected Veterans/Individuals with
Keywords: Odyssey Systems Consulting Group, Ltd., Silver Spring , Jr. Scientist II-XTAL, Other , Silver Spring, Maryland
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